Download Animal Models of Movement Disorders: Volume II by Miriam A. Hickey, Marie-Françoise Chesselet (auth.), Emma L. PDF

By Miriam A. Hickey, Marie-Françoise Chesselet (auth.), Emma L. Lane, Stephen B. Dunnett (eds.)

Movement is the way in which that animals have interaction with their atmosphere and is lower than the association and complicated keep watch over of the mind and spinal twine. a number of vital apprehensive structures, together with cortex, basal ganglia, cerebellum, and brainstem, have interaction to supply distinctive motor keep an eye on and integration. harm or sickness inside those platforms reason profound motor disturbances in guy, which might be successfully modeled in animals to boost a greater knowing and remedy of the human . Animal versions of circulation Disorders introduces quite a few equipment and strategies used to version and examine motor functionality in experimental animals from reduce orders, equivalent to drosophila and c. elegans, via vertebrate species together with fish, to mammals, akin to rodents and non-human primates. the main complex modern versions in each one approach are offered at a number of degrees of study from molecular and genetic modeling, lesions, anatomy, neurochemistry, to imaging and behaviour. Volume II of this particular assortment includes sections at the basal ganglia, neo- and allo-cortical structures, cerebellar and mind stem structures, in addition to spinal twine systems.

Comprehensive and meticulous, Animal types of move Disorders serves as a useful reference for these learning motor problems by way of overlaying methodologies intimately and delivering the data essential to ponder either the right types and evaluation instruments which can such a lot informatively solution the most important experimental concerns within the field.

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Extra resources for Animal Models of Movement Disorders: Volume II

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Pearce RA, Stringer JL, Lothman EW (1989) Effect of volatile anesthetics on synaptic transmission in the rat hippocampus. Brasted PJ, Robbins TW, Dunnett SB (1999) Distinct roles for striatal subregions in mediating response processing revealed by focal excitotoxic lesions. Pisa M (1988) Motor functions of the striatum in the rat: critical role of the lateral region in tongue and forelimb reaching. Pisa M, Cyr J (1990) Regionally selective roles of the rat’s striatum in modality-specific discrimination learning and forelimb reaching.

Reiner A, Dragatsis I, Zeitlin S et al (2003) Wild-type huntingtin plays a role in brain development and neuronal survival. Mol Neurobiol 28: 259–276. Phan J, Hickey MA, Zhang P et al (2009) Adipose tissue dysfunction tracks disease progression in two Huntington’s disease mouse models. Hum Mol Genet 18: 1006–1016. Sassone J, Colciago C, Cislaghi G et al (2009) Huntington’s disease: the current state of research with peripheral tissues. Exp Neurol 219: 385–397. Kantor O, Temel Y, Holzmann C et al (2006) Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington’s disease transgenic rats.

Epub ahead of print]. Nopoulos PC, Aylward EH, Ross CA et al (2011) Smaller intracranial volume in prodromal Huntington’s disease: evidence for abnormal neurodevelopment. Brain 134: 137–142. Say MJ, Jones R, Scahill RI et al (2011) Visuomotor integration deficits precede clinical onset in Huntington’s disease. Neuropsy­ chologia 49: 264–270. Stout JC, Paulsen JS, Queller S et al (2011) Neurocognitive signs in prodromal Huntington disease. Neuropsychology 25: 1–14. Tabrizi SJ, Scahill RI, Durr A et al (2011) Biological and clinical changes in premanifest and early stage Huntington’s disease in the TRACK-HD study: the 12-month longitudinal analysis.

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