Download AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet PDF

By Mario D. Cordero, Benoit Viollet

AMPK has emerged as a big integrator of indications that keep an eye on strength stability in the course of the rules of a number of biochemical pathways in eukaryotes.

This booklet specializes in the consequences of AMPK as a grasp metabolic regulator in ailments, together with new tools and animal versions. The contributions are written by means of prime specialists within the box and provides an intensive review of the present wisdom of AMPK biology and the function of AMPK in health and wellbeing and disorder.

Show description

Read Online or Download AMP-activated Protein Kinase PDF

Best endocrinology & metabolism books

HbA1c in Diabetes: Case studies using IFCC units

Adapting to the IFCC method of reporting HbA1c poses a problem to generations of healthiness execs who've learnt the share process concerning the foremost medical trials, in variety 1 and sort 2 diabetes, the DCCT and UKPDS. this convenient paperback illuminates the transition direction. utilizing real-life case reports to demonstrate genuine scientific events, the e-book exhibits you the way to take advantage of mmol/mol devices in day-by-day perform.

Controversies in Treating Diabetes: Clinical and Research Aspects (Contemporary Endocrinology)

This booklet addresses diabetes controversies, particularly within the administration of etiology and the illness itself. Chapters additionally learn the problems linked to diabetes. the quantity covers ordinarily accredited different types of remedies and issues, in addition to new and rising advances and cures and inadequacies in different normal remedies.

The Paraneuron

The legislation of the organism has regularly been ascribed to 2 specified systems-the worried and the endocrine. although coordination among the 2 platforms has been said, researchers and authors have tended to house them as comprising separate different types of cells focused on assorted actions.

Additional resources for AMP-activated Protein Kinase

Example text

The phosphorylation of HDAC5 on Serines 259 and 498 by AMPK was shown to be sufficient to induce GLUT4 transcription (McGee et al. 2008). AMPK can directly interact and phosphorylate PGC-1α in vitro (Canto et al. 2009). Furthermore, AMPK activation has been shown to induce activation of two transcription factors, GLUT4 enhancer factor (GEF) and myocyte enhancer factor (MEF2), both responsible for GLUT4 expression (Holmes et al. 2005; Jager et al. 2007). 2 Glycolysis Once glucose has been taken into the cell by GLUT4, it is rapidly phosphorylated into glucose-6 phosphate (G6P) by hexokinase II.

3 Glycogen Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Gluconeogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 AMPK in Lipid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Fatty Acid Uptake . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Lipid Synthesis .

6 AMPK in Protein Turnover . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 25 26 28 29 29 30 30 30 31 33 34 34 37 Abstract This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis.

Download PDF sample

Rated 4.43 of 5 – based on 46 votes